The Indianapolis Colts have officially ruled out TE Tyler Warren for Week 6 after injuring his groin in practice on Friday. He seemed to be trending on the wrong side of Questionable and with the injury occurring on Friday, there just wasn’t enough time for Warren to get healthy enough to play.
While Mo Alie-Cox is the next man up at TE, he is not nearly the threat in the passing game that Warren is. Josh Downs and Keenan Allen will be the primary receiving options for Daniel Jones in this one, but this could very well be a Jonathan Taylor game for the Colts. Laquon Treadwell and rookie Deion Burks should get some run as well. Fantasy football managers will need to monitor the Colts practice reports next week to see if Warren will be able to return in Week 7 vs. the Vikings.
Indianapolis Colts tight end Tyler Warren (groin) was ...
Indianapolis Colts tight end Tyler Warren appeared to suffer...
Indianapolis Colts tight end Tyler Warren dominated in the ...
Tyler Warren landed on Friday’s injury report after suffering a groin injury in practice and is questionable against Tennessee, another setback for a depleted Colts receiving corps. Indianapolis activated Will Mallory from injured reserve following a five-game absence with a thumb injury, providing depth behind Warren, whose 7.2 targets per game and 21.7 percent target share underscore his importance to the passing attack, per PlayerProfiler.
Warren’s 90.4 percent snap share and 83.1 percent route participation would be difficult to replace on waivers if he is inactive on Sunday. Mo Alie-Cox is the next man up for Indiapolis at the tight end position.
Adam Schefter reported that the Colts have downgraded WR Keenan Allen to out for Sunday’s Week 4 game due to his groin injury. Allen was coming off of a strong game against the Texans in Week 3, putting up 6 catches on 9 targets for 63 yards and a score.
Josh Downs and Tyler Warren will be the key pass catchers with Allen out and Alec Pierce on IR. Laquon Treadwell and the recently signed Darius Slayton will also see increased opportunities, while Jonathan Taylor may see increased targets as well. Fantasy football managers will need to keep an eye on next week’s practice reports to see how Allen is trending.
The Colts have signed veteran WR Darius Slayton, reuniting him with starting QB Daniel Jones. Slayton and Jones have established chemistry from their six seasons together in New York, and Slayton with his 102.2 (78th percentile) Speed Score brings a similar skill set to this offense as injured WR Alec Pierce (heel).
Slayton fits seamlessly into Pierce’s vertical field-stretching to open things up underneath for teammates WR Josh Downs and TE Tyler Warren. Slayton isn’t a must-add for fantasy football, as he had 37 receptions for 538 yards and 1 TD in 14 games in 2025 and struggled with drops, but he will have nominal streaming value in favorable matchups as long as Pierce is OUT. ~Jason Diaz
Colts star WR Alec Pierce aggravated the heel injury that he had surgery on, and it may lead to 2026 being a lost season for him. Rapoport also reported it’s likely Pierce will head to IR while rehabbing the heel, but surgery is still possible. The 0-2 Colts will certainly miss Pierce, who was No. 1 in the NFL in Air Yards Share a season ago at 51.8.
Josh Downs, who led the Colts with 7 catches on 9 targets in Week 2, will be one of the primary beneficiaries of Pierce’s absence. Keenan Allen looks like he’s lost a step at 34 years-old and still faces a potential suspension for his DWI and while Tyler Warren has 9 catches through 2 games, those have only led to 34 yards. Fantasy football managers will need to keep an eye on updates from Pierce in his attempt to avoid surgery.
Keenan Allen faces a baseline three-game suspension under the league substance abuse policy following two Sunday morning DWI charges. The unresolved disciplinary timeline injects immediate structural variance into an aging profile built on elite Target Share and consistent Route Participation.
Even if “parked vs. driving” technicalities somehow reduces league discipline, this legal exposure forces drafters to adjust baseline projections for missed games and question Allen’s readiness for an age-34 campaign. Josh Downs would be the clear target beneficiary of any games Allen may miss in 2026.
