Isaac Guerendo

Overall Rank
RB126
2025
Height
6' 0"
Weight
221 lbs
BMI
30.0
(50th)
Draft Pick
4.29
(2024)
College
Louisville
Age
25.4
Best Comparable Player
Isiah Pacheco
Workout Metrics
4.33
99th
125.7
100th
135.1
98th
11.09
85th
40-Yard Dash
Speed Score
Burst Score
Agility Score
Bench Press
19.4%
(38th)
College Dominator
6.1
(77th)
College YPC
6.7%
(53rd)
College Target Share
Isaac Guerendo to Miss Weeks
3 months ago

49ers Running Back Isaac Guerendo is set to miss a few weeks with a shoulder injury.

San Francisco 49ers running back Isaac Guerendo is going to miss “a few weeks” with a shoulder injury, as per Kyle Shanahan. Jordan Mason’s trade to the Minnesota Vikings earlier this offseason seemed to indicate that Guerendo would be given the first opportunity to serve as backup to Christian McCaffrey. The injuries continue to pile up for the running back. In his rookie season, he missed time due to hamstring, groin, and foot injuries. In the season finale, he suffered an MCL sprain and an ankle sprain.

 

It is frustrating news to hear, as his skill and athleticism are on display when he is in the game. The 6-foot, 220-pound back has blazing speed (4.33 40), elite explosiveness, and is an above-average receiver. In a backfield that seems to be a revolving door of injuries, fantasy managers must be tapped into the news when it comes to the 49ers. Jordan James and Isaac Guerendo are dealing with injuries, and time will tell if Christian McCaffrey is back to full health.

 

When healthy, Guerendo will be a valuable handcuff to roster, and he did show production, finishing as an RB1 for three weeks in 2024.

 

Author: Dane Madoche(@FF_DaMaddog)

 

 

Isaac Guerendo Articles & Advice

More News

Isaac Guerendo Video Analysis

See more videos @PlayerProfiler on
Start 'Em Sit 'Em Week 14 | Fantasy Football FLEX Advice to WIN YOUR LEAGUE
Crush Your Fantasy Football League: Unbeatable Strategy For Week 7 And Beyond

All Isaac Guerendo News

49ers Dealing with Some Training Camp Injuries
1 year ago

Training camp injuries are popping up early for the San Francisco 49ers.

A week after training camp has started the San Francisco 49ers have a few players missing time due to various injuries. Defensive end Drake Jackson has been ruled out for the rest of training camp with a knee injury, head coach Kyle Shanahan did not provide a timeline for his return. Along with Jackson, wide receiver Jacob Cowing and running back Isaac Guerendo are out with hamstring injuries. Cowling is only expected to miss 10 days. Guerendo will miss several weeks with his hamstring injury.

 

 

This is a blow for Drake Jackson who was drafted in the 2nd round out of USC in the 2022 NFL Draft. He has been dealing with several injuries in his short time with the Niners. Cowing and Guerendo are camp bodies at this point in camp, if they are not healthy leading up to the regular season both players may be candidates for injured reserve or worst, cut from the team altogether. Guerendo shocked the fantasy world with his athleticism on display at the NFL Combine. Athleticism doesn’t mean anything with this coaching staff unless players grasp the offense. This puts Guerendo way behind on learning this offense. The seasonal outlook is not bright for Guerendo.

49ers Rookie RB Isaac Guerendo to Contribute to Special Teams
1 year ago

Former Louisville Cardinal Isaac Guerendo looks to be 3rd on the depth chart behind starter Christian McCaffrey, and back up Elijah Mitchell.

Rookie running back Isaac Guerendo splashed onto the scene with his explosive numbers at the NFL combine. He blazed with a 4.33 second 40-yard dash, while also recording a 100th percentile Speed Score and a 98th percentile Burst Score. These metrics put Guerendo as the 8th most athletic running back all-time in the PlayerProfiler database! Measuring in at 6 foot and weighing 221 pounds, he has drawn comparisons to Jonathan Taylor. The comparison stops when it comes to production on the field. Guerendo only registered 230 carries in his 4-year college career, with his career high being 132 attempts in his Senior season. Guerendo was stuck behind fellow rookie back in Braelon Allen for the first 3 years at Wisconsin. He transferred to Louisville to get more playing time, he played every game but dealt with hamstring issues. With the 49ers, Guerendo has the same herculean task of overcoming a highly talented back on the depth chart with Christian McCaffrey leading the way. Guerendo has to contribute on special teams if he wants to make an immediate impact on the team.

 

 

 

Isaac Guerendo is as about as sexy of fantasy pick as you can get in the later rounds of dynasty leagues. He may be 3rd on the depth chart in San Francisco, but injuries have affected both backs in front of him. If both go down, it’s peddle to the metal for Guerendo to showcase that rare athleticism for Kyle Shanahan. He currently is RB65 in dynasty ADP, which I believe to be too low for his level of talent, regardless who is in front of him on the depth chart. With the running back position being so volatile he is bound to see the field and when he does, watch out! He may blaze his way into a larger role, relieving Christian McCaffrey from time to time.

Rookie RB Isaac Guerendo Learning Everything for Niners
1 year ago

Former Louisville Running Back Isaac Guerendo is learning the multifaceted RB role in Kyle Shanahan’s offense.

Isaac Guerendo is learning the 49ers offense for Kyle Shanahan. Guerendo did not have much experience playing in college until he transferred from Wisconsin to Louisville for his fifth-year senior season. He finished the season with 810 rushing yards with 11 touchdowns and 22 catches for 234 receiving yards.

 

 

When fantasy players saw Isaac Guerendo’s numbers from the combine, they had to scramble to figure out who the hell the guy is! For whatever reason Gurendo has never had a chance to truly carry a team on his back. Sadly, Guerendo will have a hard time getting on the field with the fantasy GOAT Christian McCaffrey playing. Guerendo is deep stash handcuff to McCaffrey. Should McCaffrey go down with injury, look for sparks to fly when Guerendo totes the rock!

 

Issac Guerendo Shines at Combine
1 year ago

Louisville RB Shines at Combine

Introducing Issac Guerendo, a dynamic running back hailing from Louisville with immense potential for fantasy football success. With a remarkable Relative Athletic Score of 9.99, Guerendo’s athleticism is off the charts. As a former wide receiver, he brings speed and agility to the field, evident in his impressive 4.33 40-yard dash time. In his collegiate career, Guerendo amassed 810 yards with an outstanding 6.1 yards per carry average and scored 11 touchdowns, showcasing his playmaking ability and knack for finding the end zone.

 

 

What sets Guerendo apart is his extraordinary athleticism, particularly for his size. He holds the title for the fastest 40-yard dash among players weighing 220 pounds or more, a feat unmatched in recent history. Additionally, he ranks in the top five for vertical jump and broad jump among players of similar weight over the past two decades, highlighting his explosive power and leaping ability.

 

 

Fantasy football enthusiasts should take note of Guerendo as a late-round steal with the potential to deliver significant returns. His combination of speed, athleticism, and playmaking skills make him a valuable asset to any fantasy roster, poised to make a notable impact in the upcoming season.

San Francisco 49ers Draft Isaac Guerendo With 129th Pick
1 year ago

The San Francisco 49ers have selected running back Isaac Guerendo from the University of Louisville with the 129th pick in the 2024 NFL Draft.

After being buried in Wisconsin’s running back room, Isaac Guerendo transferred to Louisville and made himself known his senior season 810 yards (6.1 YPC) and 11 touchdowns. He also added 22 catches for 232 yards. Guerendo was a big time combine winner after absolutely lighting up every test thrown at him. He posted a 4.33 40-yard dash, a 41.5 inch vertical jump, and a 10’9” broad jump which was good enough for a relative athletic score of 9.98. Very impressive for his size at 6’0” and 221 pounds.

 

Guerendo now finds himself in a decent fantasy situation for a later pick. Yes, he is stuck behind Christian McCaffrey, but Elijah Mitchell is entering the last year of his deal and Guerendo should find himself as McCaffrey’s primary backup by 2025. Guerendo’s speed should pair well into the 49ers running scheme and we’ve seen how valuable that 49ers backup running back spot has been in the past. The 49ers also traded up for Guerendo showing he was a player they specifically sought out. You should have no reservations taking a shot at Guerendo in the later rounds of your rookie drafts and he would make a great taxi squad stash for a year.